Contact Us Search Paper

Detection of Alzheimer’s Disease and Dementia States Based on Deep Learning from MRI Images: A Comprehensive Review

Emre Altinkaya1, Kemal Polat2,*, Burhan Barakli3

Corresponding Author:

Kemal Polat

Affiliation(s):

1 Ph.D. Student at School of Natural Sciences, Department of Electrical and Electronics Engineering, Sakarya University, Sakarya, Turkey, Email: [email protected]
2 Department of Electrical and Electronics Engineering, Faculty of Engineering, Bolu Abant Izzet Baysal University, 14280, Bolu, Turkey, Email: [email protected]
3 Department of Electrical and Electronics Engineering, Sakarya University, Sakarya, Turkey,
Email: [email protected]
*Corresponding Author: Prof. Kemal Polat, Email: [email protected]

Abstract:

Many studies have been conducted to examine abnormal conditions in brain structures and to detect Alzheimer's and Dementia states using features derived from medical images. From these data, it is very important to detect the diagnosis of Alzheimer's and Dementia disease early and to provide appropriate treatment to the patients. Quality magnetic resonance (MR) images are requested to make this diagnosis. But while producing a quality image, it also brings less spatial coverage and longer scanning and identification time. In this context, biomedical image processing has undergone a serious expansion and has become an interdisciplinary research field that includes many fields. Computer Aided systems have become an important part in the diagnosis process. With the development of computer aided systems, producing quality information for the diagnosis of disease in image processing applications has caused various problems. Such difficulties are tried to be overcome with artificial intelligence technology and super-resolution (SR), which has gained great importance in image processing lately. Using the super resolution methodology, a high resolution image is obtained from the low resolution image. Thus, the image processing timing is shortened and an image with desired features can be obtained. This shortens the irritating and long-lasting MR imaging process. In addition, it provides convenience for the diagnosis of the disease with the improvements it provides on MR images. Recovering the image is an important step in this process. The quality of the reconstructed image depends on the restoration methods. The functionality of artificial intelligence technology in image processing and biomedical fields is increasing day by day. The deep learning method is preferred in techniques aimed at obtaining a reconstructed quality image. At the same time, various artificial intelligence methods are widely used for classifying and detecting the data obtained. One of the most common of these is neural network (NN) methods.. Deep learning, a special method of neural networks, is widely used in classification methods due to its superior structural properties. When studies are examined, it is seen that DL methods are widely used. The success of the proposed methods is increasing day by day.

Keywords:

Alzheimer's disease; Dementia disease; super-resolution; Deep learning

Downloads: 2078 Views: 7240
Cite This Paper:

Emre Altinkaya, Kemal Polat, Burhan Barakli (2019). Detection of Alzheimer’s Disease and Dementia States Based on Deep Learning from MRI Images: A Comprehensive Review. Journal of the Institute of Electronics and Computer, 1, 39-53. https://doi.org/10.33969/JIEC.2019.11005.

References:

[1] Kennedy, D. P., and Adolphs, R. (2012) The social brain in psychiatric and neurological disorders. Trends Cogn Sci 16(11):559–572.
[2] Orru, G., Pettersson-Yeo, W., Marquand, A. F., Sartori, G., and Mechelli, A., (2012) Using SVM to identify imaging biomarkers of neurological and psychiatric disease: A critical review. Neurosci Biobehav Rev 36(4):1140–1152.
[3] Spasov, S., Passamonti, L., Duggento, A., Lio, P., and Toschi, N. (2019) Alzheimer's Disease Neuroimaging Initiative. A parameterefficient deep learning approach to predict conversion from mild cognitive impairment to Alzheimer's disease. NeuroImage 189: 276–287.
[4] Cheng, D., and Liu,M. (2017) CNNs based multi-modality classification for AD diagnosis. In 2017 10th international conference on image and signal processing, BioMedical Engineering and Informatics, IEEE, 1-5.
[5] Farooq, A., Anwar, S., Awais, M., and Rehman, S. (2017) A deep CNN based multi-class classification of Alzheimer's disease usingMRI. In 2017 IEEE international conference on imaging systems and techniques, IEEE, 1-6.
[6] Gunawardena, K. A. N. N. P., Rajapakse, R. N., and Kodikara, N. D. (2017) Applying convolutional neural networks for pre-detection of alzheimer's disease from structural MRI data. In 2017 24th international conference on mechatronics and machine vision in practice, IEEE, 1-7.
[7] Billones, C. D., Demetria, O. J. L. D., Hostallero, D. E. D., and Naval, P. C. (2016) DemNet: A Convolutional Neural Network for the Detection of Alzheimer's Disease and Mild Cognitive Impairment. In IEEE Region 10 Conference, 3724–3727.
[8] Payan, A., and Montana, G. (2015) Predicting Alzheimer's disease: a neuroimaging study with 3D convolutional neural networks. arXiv preprint arXiv:1502.02506:1–9.
[9] McKhann, G. et al., (1984) Clinical diagnosis of Alzheimer’s disease: Report of the NINCDSADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, vol. 34, no. 7, pp. 939.
[10] Christodoulou, AG., Zhang, H., Zhao, B., Hitchens, TK., Ho, C. and Liang, ZP. (2013) High-resolution cardiovascular MRI by integrating parallel imaging with low-rank and sparse modeling. IEEE Trans Biomed Eng. 2013 Nov;60(11):3083-92. doi: 10.1109/TBME.2013.2266096.
[11] Helms, C., (2008). Musculoskeletal MRI. Saunders. ISBN 978-1-4160-5534-1.
[12] Baboi, LM. et al., (2007) Characterization of neuro-endocrine tumors in an athymic nude mouse model using dedicated synchronization strategies for T2-weigted MR imaging at 7T. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:2879-82.
[13] Zhaoyang, J., Yiping, P.D. (2012) Application of partial-echo compressed sensing in MR angiography. 5th International Conference on BioMedical Engineering and Informatics. doi: 10.1109/BMEI.2012.6513105.
[14] Sarraf, S. and Tofighi, G. (2016) Classification of Alzheimer's Disease using fMRI Data and Deep Learning Convolutional Neural Networks.  Computer Vision and Pattern Recognition.  arXiv:1603.08631 [cs.CV]
[15] Alzheimer’s Association et al., (2014) Alzheimer’s disease facts and figures, Alzheimers Dement, vol. 10, no. 2, pp. e47–e92, 2014.
[16] Sharma, M., Singh,G., and Singh, R., (2017) Stark assessment of lifestyle based human disorders using data mining based learning techniques. IRBM. 38:305–324.
[17] Gautam, R., Kaur, P., and Sharma, M., (2019) A comprehensive review on nature-inspired computing algorithms for the diagnosis of chronic disorders in human beings. Progress in Artificial Intelligence. 8(4):1–24.
[18] Kaur, P., and Sharma, M., (2019) Diagnosis of human psychologicaldisorders using supervised-learning and nature-inspired computing techniques: A meta-analysis. J Med Syst 43(7):204.
[19] Hosseini-Asl, E., Keynton, R., El-Baz, A., (2016) Alzheimer's disease diagnostics by adaptation of 3D convolutional network. IEEE International Conference on Image Processing (ICIP).
[20] Gautam, R. and Sharma, M. (2020) Prevalence and Diagnosis of Neurological Disorders Using Different Deep Learning Techniques: A Meta-Analysis. Journal of Medical Systems volume 44, Article number: 49 (2020). https://doi.org/10.1007/s10916-019-1519-7.
[21] Jack, C.R. et al., (2011) Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.  Alzheimers Dement, vol. 7, no. 3, pp. 257–262.
[22] McKhann, G.M. et al., (2011) The diagnosis of dementia due to Alzheimers disease: Recommendations from the National Institute on Aging-Alzheimers Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement, vol. 7, no. 3, pp. 263–269.
[23] Bron, E.E. et al., (2015) Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: The CADDementia challenge. NeuroImage.
[24] Cuingnet, R. et al., (2011) Automatic classification of patients with Alzheimer’s disease from structural MRI: a comparison of ten methods using the ADNI database.  NeuroImage, vol. 56, no. 2, pp. 766–781.
[25] Falahati, F. et al., (2014) Multivariate Data Analysis and Machine Learning in Alzheimer’s Disease with a Focus on Structural Magnetic Resonance Imaging.  J. of Alzheimer Dis, vol. 41, no. 3, pp. 685–708.
[26] Sabuncu, M.R. et al., (2015) Clinical Prediction from Structural Brain MRI Scans: A Large-Scale Empirical Study. Neuroinformatics, vol. 13, no. 1, pp. 31–46.
[27] Deng, L., (2014) A tutorial survey of architectures, algorithms, and applications for deep learning. APSIPA Transactions on Signal and Information Processing 3:1–29.
[28] Gulhare, K. K., (2017) Shukla, S. P., and Sharma, L. K., Deep Neural Network Classification method to Alzheimer’s Disease Detection. International Journals of Advanced Research in Computer Science and Software Engineering 7(6):1–4
[29] Long, M. and Wang, J. (2015) Learning transferable features with deep adaptation networks.  arXiv:1502.02791 [cs.LG].
[30] Ravì, D., Wong, C., Deligianni, F., Berthelot, M., Andreu-Perez, J., Lo, B., and Yang, G., (2017) Deep learning for health informatics. IEEE Journal Of Biomedical and Health Informatics 21(1):4–21.
[31] Pouyanfar, S., Sadiq, S., Yan, Y., Tian, H., Tao, Y., Reyes, M. P., and Iyengar, S. S., (2018) A survey on deep learning: Algorithms, techniques, and applications. ACM Computing Surveys (CSUR) 51(5): 92.
[32] Dolph, C. V., Alam, M., Shboul, Z., Samad, M. D., and Iftekharuddin, K. M., (2017) Deep learning of texture and structural features for multiclass Alzheimer's disease classification. In 2017 International Joint Conference on Neural Networks, 2259–2266.
[33] Rieke, J., Eitel, F., Weygandt, M., Haynes, J. D., and Ritter, K., (2018) Visualizing convolutional networks for MRI-based diagnosis of Alzheimer’s disease. In Understanding and Interpreting Machine Learning in Medical Image Computing Applications, Springer, Cham, 24-31.
[34] Benyoussef, E. M., Elbyed, A., and El Hadiri, H., (2018) 3D MRI classification using KNN and deep neural network for Alzheimer’s disease diagnosis. In International Conf. on Advanced Intelligent Sys. Sustainable Development, Springer, Cham, 154–158.
[35] Basaia, S., Agosta, F., Wagner, L., Canu, E., Magnani, G., and Santangelo, R., (2019) Alzheimer's Disease Neuroimaging Initiative: Automated classification of Alzheimer's disease and mild cognitive impairment using a single MRI and deep neural networks. NeuroImage: Clinical 21(1-8):101645.
[36] Kim, D., and Kim, K. (2018) Detection of Early Stage Alzheimer’s Disease using EEG Relative Power with Deep Neural Network. In 40th Annual International Conference of the IEEE Engg. in Medicine and Bio. Society, 352–355.
[37] Cireşan, D. C., Giusti, A., Gambardella, L. M., and Schmidhuber. (2013) Mitosis detection in breast cancer histology images with deep neural networks. In International Conf. on Med. Image-Computing and Computer-assisted Intervention, Springer, Heidelberg, 411–418.
[38] Ramesh, S., Caytiles, R. D., and Iyengar, N. C. S. (2017) Adeep-learning approach to identify diabetes. Advanced Science and Tech Letter 145:44–49.
[39] Ma, X., Yang, H., Chen, Q., Huang, D., and Wang, Y. (2016) Depaudionet: An efficient deep model for audio-based depression classification. In Proceedings of the 6th International Workshop on Audio/Visual Emotion Challenge, ACM, 35–42.
[40] Heinsfeld, A. S., Franco, A. R., Craddock, R. C., Buchweitz, A., and Meneguzzi, F. (2018) Identification of autism spectrum disorder using deep learning and the ABIDE dataset. NeuroImage: Clinical 17:16–23.
[41] Daoud, H. G., Abdelhameed, A.M., and Bayoumi,M. (2018) Automatic epileptic seizure detection based on empirical mode decomposition and deep neural network. In 2018 IEEE 14th International Colloquium on Signal Processing & Its Applications (CSPA) IEEE, 182–186.
[42] Kadam, V. J., and Jadhav, S. M. (2019) Feature Ensemble Learning Based on Sparse Auto-encoders for Diagnosis of Parkinson’s Disease. In Computing, Communication and Signal Processing, Springer, Singapore. 810:567–581.
[43] Kim, J., Kang, U., and Lee, Y. (2017) Statistics and deep belief networkbased cardiovascular risk prediction. Healthcare Informatics Research 23(3)169–175.
[44] Cai, H., Sha, X., Han, X., Wei, S., and Hu, B. (2016) Pervasive EEG diagnosis of depression using Deep Belief Network with threeelectrodes EEG collector. In 2016 IEEE International Conference on Bioinformatics and Biomedicine, 1239–1246.
[45] Shi, B., Chen, Y., Zhang, P., Smith, C. D., and Liu, J. (2017) Alzheimer's Disease Neuroimaging Initiative:Nonlinear feature transformation and deep fusion for Alzheimer's Disease staging analysis. Pattern Recogn 63:487–498.
[46] Bhatkoti, P., and Paul,M. (2016) Early diagnosis of Alzheimer's disease: A multi-class deep learning framework with modified k-sparse autoencoder classification. In International Conference on Image and Vision Computing New Zealand, IEEE, 1-5.
[47] Xu, J., Xiang, L., Liu, Q., Gilmore, H., Wu, J., Tang, J., and Madabhushi, A. (2016) Stacked sparse autoencoder for nuclei detection on breast cancer-histopathology images. IEEE Trans Med Imaging 35(1):119–130.
[48] Chen, L., Zhou, M., Su, W., Wu, M., She, J., and Hirota, K. (2018) Softmax regression-based deep sparse autoencoder network for facial emotion recognition in human-robot interaction. Inf Sci 428:49–61.
[49] Cui, R., Liu, M. (2019) Alzheimer's disease neuroimaging initiative: RNN-based longitudinal analysis for diagnosis of Alzheimer-disease. Computerized Med. Imaging and Graphics, 1-25.
[50] Suk, H. I., Lee, S. W., and Shen, D. (2014) Alzheimer's disease neuroimaging InitiativeHierarchical feature representation and multimodal fusion with DL for AD/MCI diagnosis. Neuroimage. 101: 569–582.
[51] Awate, G., Bangare, S., Pradeepini, G., and Patil, S. (2018) Detection of Alzheimers Disease from MRI using Convolutional Neural Network with Tensorflow. arXiv preprint arXiv:1806.10170.
[52] Sarraf, S., DeSouza, D. D., Anderson, J., and Tofighi, G. (2017) DeepAD: Alzheimer′ s disease classification via deep convolutional neural networks using MRI and fMRI. BioRxiv, 070441:1–15.
[53] Kruthika, K. R., and Maheshappa, H. D. (2019) Alzheimer's disease neuroimaging initiative: CBIR system using capsule networks and 3D CNN for Alzheimer's disease diagnosis. Informatics in Medicine Unlocked 14:59–68.
[54] Aderghal, K., Khvostikov, A., Krylov, A., Benois-Pineau, J., Afdel, K., and Catheline, G., (2018) Classification of Alzheimer Disease on Imaging Modalities with Deep CNNs Using Cross-Modal Transfer Learning. In 2018 IEEE 31st international symposium on computer-based medical systems, IEEE, 345-350.
[55] Tang, H., Yao, E., Tan, G., and Guo, X. (2018) A Fast and Accurate 3D Fine-Tuning Convolutional Neural Network for Alzheimer’s Disease Diagnosis. In International CCF Conference on Artificial Intelligence, Springer, Singapore, 115–126.
[56] Cui, R., and Liu, M. (2018) Hippocampus Analysis by Combination of 3D DenseNet and Shapes for Alzheimer's Disease Diagnosis. IEEE J Biomed Health Inform 23(5):1–8.
[57] Wang, H., Shen, Y., Wang, S., Xiao, T., Deng, L., Wang, X., and Zhao, X. (2019) Ensemble of 3D densely connected convolutional network for diagnosis of mild cognitive impairment and Alzheimer’s disease. Neurocomputing 333:145–156.
[58] Kumar, S., Negi, A., and Singh, J. N. (2019) Semantic Segmentation Using Deep Learning for Brain Tumor MRI via Fully Convolution Neural Networks. In Information and Communication Technology for Intelligent Systems, Springer, Singapore,11–19.
[59] Ren, X., Xiang, L., Nie, D., Shao, Y., Zhang, H., Shen, D., and Wang, Q. (2018) Interleaved 3D-CNN s for joint segmentation of small volume structures in head and neck CT images. Med Phys 45(5): 2063–2075.
[60] Yang, H., Zhang, J., Liu, Q., and Wang, Y. (2018) Multimodal MRIbased classification of migraine: using deep learning CNN. Biomedical engineering online 17 (1): 138.
[61] Li, G., Liu, M., Sun, Q., Shen, D., and Wang, L., (2018) Early diagnosis of autism disease by multi-channel CNNs. In International Workshop on Machine Learning in Medical Imaging, Springer, Cham,303–309.
[62] Wang, S.H., Phillips, P., Sui,Y., Liu, B., Yang, M., and Cheng, H. (2018) Classification of Alzheimer’s disease based on eight-layer convolutional neural network with leaky rectified linear unit and max pooling. J Med Syst 42(5):85.
[63] Islam, J., and Zhang, Y. (2017) A novel deep learning based multi-class classification method for Alzheimer’s disease detection using brain MRI data. In International Conference on Brain Informatics,Springer, Cham, 213–222.
[64] Feigin, V. L., Abajobir, A. A., Abate, K. H., Abd-Allah, F., Abdulle, A. M., Abera, S. F., and Aichour, M. T. E., Global, regional, and national burden of neurological disorders during 1990–2015: A systematic analysis for the global burden of disease study 2015. The Lancet Neurology 16(11):877–897, 2017.